Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of <scp>RCHY1</scp> ‐mediated <scp>P53</scp> ubiquitination
This study elucidates that Gorab mutations in the dermis promote skin aging by causing P53 accumulation and disrupting ECM expression via epigenetic regulation. These findings clarify the biological role of Gorab in skin aging and provide a theoretical basis for related mechanistic research and potential preventive strategies.
Authors
- Yanhong Li (ORCID: https://orcid.org/0009-0007-1456-8050)
- Wenjie Zhao (ORCID: https://orcid.org/0009-0002-7416-7164)
- Yunlin Han
- Yanfeng Xu
- Wei Liang
- Siyuan Wang
- Chuan Qin
- Wei Deng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1002/ame2.70165
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00