Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry

Despite the dominant role of cumulative LDL-C burden in the development of CAD, our findings indicate an association between hypertension and CAD in HoFH. Although causal inference is limited by the cross-sectional design, these results highlight the importance of proactive identification and management of hypertension in HoFH alongside intensive lipid-lowering therapy.

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Publication Details

Journal
Atherosclerosis
Published
2026-03-24
DOI
https://doi.org/10.1016/j.atherosclerosis.2026.120717
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
Field-Weighted Citation Impact
0.00
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article

Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry

Laurens F. Reeskamp, Laura D’Erasmo, Willemijn A.M. Schonck, Jeanine E. Roeters van Lennep et al.
Atherosclerosis
Lipoproteins and Cardiovascular Health
article

Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry

Laurens F. Reeskamp, Laura D’Erasmo, Willemijn A.M. Schonck, Jeanine E. Roeters van Lennep, Fahad Alnouri, Alberico L. Catapano, Dirk J. Blom, Tycho Tromp, Erik S.G. Stroes, G. Kees Hovingh, Aeilko H. Zwinderman, Frederick J. Raal, Marina Cuchel, Akl C. Fahed
article en

Abstract

Despite the dominant role of cumulative LDL-C burden in the development of CAD, our findings indicate an association between hypertension and CAD in HoFH. Although causal inference is limited by the cross-sectional design, these results highlight the importance of proactive identification and management of hypertension in HoFH alongside intensive lipid-lowering therapy.

AtherosclerosisVol. 415
Broad Institute (US), Prince Sultan University (SA), University of Cape Town (ZA), University of the Witwatersrand (ZA), Erasmus MC (NL), Massachusetts General Hospital (US), MultiMedica (IT), St. Antonius Ziekenhuis (NL), Department of Public (IN), Erasmus MC Cancer Institute (NL), Public Health Service of Amsterdam (NL), Amsterdam University Medical Centers (NL), University of Pennsylvania (US), Sapienza University of Rome (IT), University of Amsterdam (NL), Erasmus University Rotterdam (NL)
Good health and well-being
Openalex Percentile: Top 12%
Lipoproteins and Cardiovascular Health
DOIOpen Access PDFOpenAlex
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Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry — Laurens F. Reeskamp, Laura D’Erasmo, et al. · Atherosclerosis (2026) | TGRS Research Map | TGRS