Nodal Upstaging and Oncologic Outcomes After Segmentectomy Versus Lobectomy for Early-Stage Non-Small Cell Lung Cancer
When performed with systematic nodal dissection, adequate surgical margins, and appropriate adjuvant therapy, segmentectomy appears to provide survival outcomes comparable to lobectomy in selected patients with early-stage NSCLC. Completion lobectomy may not be routinely required and should be considered on a case-by-case basis within a multidisciplinary context. These findings support the use of segmentectomy in carefully selected patients when high-quality surgical staging and integrated oncologic care are ensured, while highlighting the need for prospective studies addressing occult nodal disease in the modern treatment era.
Authors
- Alecsandra A Tudor
- Michel González (ORCID: https://orcid.org/0000-0001-8705-4279)
- Edoardo Zanfrini (ORCID: https://orcid.org/0000-0003-4158-7963)
- Ye Tian (ORCID: https://orcid.org/0000-0003-4388-7118)
- Thorsten Krueger (ORCID: https://orcid.org/0000-0002-0546-239X)
- Etienne Abdelnour-Berchtold
- Jean Yannis Perentes
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-23
- DOI
- https://doi.org/10.3390/cancers18061039
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00