Nodal Upstaging and Oncologic Outcomes After Segmentectomy Versus Lobectomy for Early-Stage Non-Small Cell Lung Cancer

When performed with systematic nodal dissection, adequate surgical margins, and appropriate adjuvant therapy, segmentectomy appears to provide survival outcomes comparable to lobectomy in selected patients with early-stage NSCLC. Completion lobectomy may not be routinely required and should be considered on a case-by-case basis within a multidisciplinary context. These findings support the use of segmentectomy in carefully selected patients when high-quality surgical staging and integrated oncologic care are ensured, while highlighting the need for prospective studies addressing occult nodal disease in the modern treatment era.

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Publication Details

Journal
Cancers
Published
2026-03-23
DOI
https://doi.org/10.3390/cancers18061039
Primary Topic
Lung Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Nodal Upstaging and Oncologic Outcomes After Segmentectomy Versus Lobectomy for Early-Stage Non-Small Cell Lung Cancer

Alecsandra A Tudor, Michel González, Edoardo Zanfrini, Ye Tian et al.
Cancers
Lung Cancer Diagnosis and Treatment
article

Nodal Upstaging and Oncologic Outcomes After Segmentectomy Versus Lobectomy for Early-Stage Non-Small Cell Lung Cancer

Alecsandra A Tudor, Michel González, Edoardo Zanfrini, Ye Tian, Thorsten Krueger, Etienne Abdelnour-Berchtold, Jean Yannis Perentes
article en

Abstract

When performed with systematic nodal dissection, adequate surgical margins, and appropriate adjuvant therapy, segmentectomy appears to provide survival outcomes comparable to lobectomy in selected patients with early-stage NSCLC. Completion lobectomy may not be routinely required and should be considered on a case-by-case basis within a multidisciplinary context. These findings support the use of segmentectomy in carefully selected patients when high-quality surgical staging and integrated oncologic care are ensured, while highlighting the need for prospective studies addressing occult nodal disease in the modern treatment era.

CancersVol. 18(6)
Centre Hospitalier Universitaire Vaudois (CH), University of Lausanne (CH)
Good health and well-being
Openalex Percentile: Top 12%
Lung Cancer Diagnosis and Treatment
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