Lingguizhugan Decoction Alleviates Lung Inflammatory in Obstructive Sleep Apnea by Modulating ROS and HIF‐1α Signaling Pathway Based on UHPLC–MS, Network Pharmacology, Transcriptomics, and Experimental Verification
LGZG alleviates CIH-induced pulmonary inflammation, neutrophil infiltration, and IL-6 secretion in mice. These effects are associated with the suppression of ROS production and inhibition of the HIF-1α signaling pathway.
Authors
- Yipeng Sun (ORCID: https://orcid.org/0009-0000-3862-4597)
- Jinjin Liu (ORCID: https://orcid.org/0000-0002-6023-4517)
- Li Han
- Rui Chen
- Mengyu Liu
Institutions
- Soochow University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Yueyang Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1002/rcm.70064
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00