Recellularized Humanized Bioengineered Biatrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies
A novel, light-controllable, bioengineered humanized biatrial tissue model was established and could be used to model different atrial arrhythmias, for drug testing, for disease modeling, and for evaluation of novel therapeutic interventions such as biological pacemaking and optogenetic interventions.
Authors
- Yehuda Wexler (ORCID: https://orcid.org/0000-0002-9586-9109)
- Irit Huber
- Stephanie Protze (ORCID: https://orcid.org/0000-0002-7993-3780)
- Assad Shiti (ORCID: https://orcid.org/0000-0001-5942-2513)
- Amit Gruber (ORCID: https://orcid.org/0000-0002-6366-3093)
- Lior Gepstein (ORCID: https://orcid.org/0000-0002-5351-7391)
- Maggie Kwan
- Oded Edri
- Michal Landesberg
- Daniel Shiff
- Matteo Ghiringhelli (ORCID: https://orcid.org/0000-0003-2191-6942)
- Shany Glatstein (ORCID: https://orcid.org/0000-0001-5467-0761)
- Harel Grinstein
- Gil Arbel
- Tahel Kerem
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Rambam Health Care Campus (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
- Stem Cell Network (CA)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1161/circresaha.125.326884
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00