Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study
Neurocognitive disorders are complex entities, where cognitive and neuropsychiatric symptoms are not fully influenced by the same factors. When cognitive symptoms seem more driven by cerebral pathology than frailty, neuropsychiatric symptoms appear to be more influenced by general state of frailty. Measuring and treating frailty might be a key factor in dealing with neuropsychiatric symptoms and their consequences.
Authors
- Frédéric Gervais (ORCID: https://orcid.org/0000-0003-3672-402X)
- François Cotton (ORCID: https://orcid.org/0000-0003-0046-2478)
- Anthime Flaus (ORCID: https://orcid.org/0000-0001-5877-2159)
- Sandrine Louchart de la Chapelle
- Anthony Bathsavanis
- Christophe Hirtz (ORCID: https://orcid.org/0000-0002-7313-0629)
- Achille Teillac
- Nawèle Boublay (ORCID: https://orcid.org/0000-0002-2074-0298)
- Sophie Dautricourt (ORCID: https://orcid.org/0000-0001-8848-8300)
- Teddy Novais (ORCID: https://orcid.org/0000-0003-1606-8635)
- Pierre Krolak-Salmon
- Marc Verny
- Victor Gilles
- Thomas DESMIDT
- Sylvain Lehmann
- Frédéric Blanc
- Constance Dumay
- Antoine Garnier-Crussard
- Virginie Desestret
- Mathilde Sauvée
- Marc Paccalin
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon College (US)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Princess Grace Hospital Centre (MC)
- Université de Poitiers (FR)
- Sorbonne Université (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Laboratoire de Psychologie et NeuroCognition (FR)
- Clinical Investigation Center Plurithematic Tours (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Pitié-Salpêtrière Hospital (FR)
- Adaptation Biologique et Vieillissement (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- The Journal of Frailty & Aging
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1016/j.tjfa.2026.100148
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00