Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project

Our study highlights key molecular and immune differences across R/M SCCHN subgroups, identifies potential biomarkers, and suggests biological rationales for tailored therapeutic strategies.

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Publication Details

Journal
Clinical Cancer Research
Published
2026-03-23
DOI
https://doi.org/10.1158/1078-0432.ccr-25-3377
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
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article

Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project

Sylvie Rusakiewicz, Lucas Michon, Henoch S. Hong, A. van der Elst et al.
Clinical Cancer Research
Head and Neck Cancer Studies
article

Molecular and immune landscape of recurrent and/or distant metastatic squamous cell carcinoma of the head and neck: an EORTC/IMMUCAN project

Sylvie Rusakiewicz, Lucas Michon, Henoch S. Hong, A. van der Elst, Loredana Martignetti, Robin Liechti, R. Galot, Júlio Oliveira, Daniel Herrero-Saboya, Bruno Palau Fernandez, P Devanand, Marie-Sophie Robert, Paul-Antoine Nicolas, D. Schulz, M. Morfouace, Maya Persoons, Sophie Déglise, M. Pracht, Paolo Bossi, Stephanie Tissot, Jean-Pascal Machiels, Bernd Bodenmiller, Céline Lefebvre, Pierre Saintigny, Caroline Even, Nils Eling
article en

Abstract

Our study highlights key molecular and immune differences across R/M SCCHN subgroups, identifies potential biomarkers, and suggests biological rationales for tailored therapeutic strategies.

Clinical Cancer Research
Université Claude Bernard Lyon 1 (FR), European Organisation for Research and Treatment of Cancer (NL), SIB Swiss Institute of Bioinformatics (CH), Cliniques Universitaires Saint-Luc (BE), Humanitas University (IT), Merck KGaA, Darmstadt (Germany) (DE), Lyon College (US), University of Zurich (CH), European CanCer Organisation (BE), Institut Gustave Roussy (FR), Centre Hospitalier Universitaire Vaudois (CH), ETH Zurich (CH), Institute for Biomedical Engineering (CH), Centre Léon Bérard (FR), Centre Eugène Marquis (FR), IPO Porto (PT), Ludwig Cancer Research (CH), European Organisation for Research and Treatment of Cancer (BE), Servier (France) (FR), Physique des Cellules et Cancers (FR), Institut Curie (FR), University of Lausanne (CH)
Openalex Percentile: Top 10%
Head and Neck Cancer Studies
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