Structural Design of T-Cell Epitope-Based mRNA Vaccine Constructs Determines the Quality of T-Cell Immunity and Protective Efficacy Against SARS-CoV-2 in Mice
These findings establish a direct link between construct design parameters and T-cell polarization quality, and provide a rational framework for next-generation epitope-based mRNA vaccine development.
Authors
- Denis A. Kleymenov (ORCID: https://orcid.org/0000-0001-9422-7238)
- Aleksandr Gintsburg
- Evgeniia N. Bykonia (ORCID: https://orcid.org/0000-0002-2269-1469)
- S. B. Kozlova (ORCID: https://orcid.org/0000-0001-7785-0407)
- Elena P. Mazunina (ORCID: https://orcid.org/0000-0003-0701-5152)
- Amir I. Tukhvatulin (ORCID: https://orcid.org/0000-0001-8506-2339)
- Daria M. Grousova (ORCID: https://orcid.org/0000-0002-3299-4818)
- Ilya D. Zorkov (ORCID: https://orcid.org/0000-0001-8311-2283)
- Anna A. Iliukhina (ORCID: https://orcid.org/0000-0003-0728-5478)
- Alina S. Dzharullaeva (ORCID: https://orcid.org/0000-0003-1743-0798)
- Dmitriy N. Shcherbinin
- Evgeny V. Usachev (ORCID: https://orcid.org/0000-0001-5197-2465)
- D. Y. Logunov
- Andrei A. Pochtovyi
- Inna V. Shuliakova
- Andrei E. Siniavin
- Anastasia S. Ungur
- Vladimir A. Gushchin
Institutions
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Vaccines
- Published
- 2026-03-23
- DOI
- https://doi.org/10.3390/vaccines14030281
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00