Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients With Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies

Although the sample size is small, these findings support the clinical benefit of zanidatamab treatment for HER2-positive SGC.

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Publication Details

Journal
Clinical Cancer Research
Published
2026-03-23
DOI
https://doi.org/10.1158/1078-0432.ccr-25-4158
Primary Topic
HER2/EGFR in Cancer Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients With Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies

Muralidhar Beeram, Emanuele Loro, Kay T. Yeung, Kavita Shah et al.
Clinical Cancer Research
HER2/EGFR in Cancer Research
article

Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients With Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies

Muralidhar Beeram, Emanuele Loro, Kay T. Yeung, Kavita Shah, Diana Shpektor, Douglas S. Fuller, T. Samuel Nached, Keun-Wook Lee, Toshihiko Doi, Elena Elimova, Do-Youn Oh, Funda Meric-Bernstam
article en

Abstract

Although the sample size is small, these findings support the clinical benefit of zanidatamab treatment for HER2-positive SGC.

Clinical Cancer Research
The University of Texas MD Anderson Cancer Center (US), National Foundation for Cancer Research (US), New Generation University College (ET), Princess Margaret Cancer Centre (CA), Seoul National University Bundang Hospital (KR), Jazz Pharmaceuticals (United States) (US), South Texas Accelerated Research Therapeutics (US), Jazz Pharmaceuticals (Italy) (IT), National Cancer Center Hospital East (JP), Jazz Pharmaceuticals (France) (FR)
Good health and well-being
Openalex Percentile: Top 12%
HER2/EGFR in Cancer Research
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Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients With Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies — Muralidhar Beeram, Emanuele Loro, et al. · Clinical Cancer Research (2026) | TGRS Research Map | TGRS