Age, sex, smoking-specific prevalence and progression in interstitial lung abnormality: patient-level meta-analysis
Age is the strongest determinant of ILA prevalence. ILAs show significant progression on imaging over time, and progression is mainly driven by fibrotic features rather than age once ILA is established. Given the higher prevalence in older adults, targeted screening in aging populations remains appropriate, while follow-up strategies should be guided by fibrotic burden rather than age.
Authors
- Gong Jin
- Richard Hewitt (ORCID: https://orcid.org/0000-0003-4294-0052)
- Yeon Joo Jeong
- Jong Eun Lee (ORCID: https://orcid.org/0000-0002-8754-6801)
- Rachel K. Putman (ORCID: https://orcid.org/0000-0002-8027-7450)
- Kerri A. Johannson (ORCID: https://orcid.org/0000-0003-1205-5511)
- H. Hatabu
- John A. Mackintosh (ORCID: https://orcid.org/0000-0002-5254-4144)
- Conal Hayton (ORCID: https://orcid.org/0000-0001-8907-0643)
- I Buendía-Roldán
- Claire C. Cutting
- Emily Bartlett (ORCID: https://orcid.org/0000-0002-4940-2567)
- Ugo Pastorino
- Hyunsook Hong
- Kum Ju Chae
- M Selman
- Soyeoun Lim
- Peter M George
- Gary M Hunninghake
- Nicola Sverzellati
- Avignat S Patel
- Jin Mo Goo
- Anna J Podolanczuk
- R Graham Barr
- Anand Devaraj
- Alain Tremblay
- David A Lynch
- Soon Ho Yoon
- Haval Balata
Institutions
- Tufts University (US)
- University of Parma (IT)
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- Seoul National University (KR)
- University of Calgary (CA)
- Cancer Research Institute (US)
- King's College London (GB)
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Manchester Academic Health Science Centre (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Asan Medical Center (KR)
- New Generation University College (ET)
- Harefield Hospital (GB)
- Seoul National University Hospital (KR)
- National Jewish Health (US)
- Institute of Cancer Research (CA)
- Royal Brompton Hospital (GB)
- Research Institute of Radiology (BY)
- Lung Institute (US)
- Instituto Nacional de Enfermedades Respiratorias (MX)
- Lahey Medical Center (US)
- Alberta Cancer Foundation (CA)
- Prince Charles Hospital (AU)
- Jeonbuk National University Hospital (KR)
- Ulsan University Hospital (KR)
- National Medical Center (KR)
- Pusan National University Yangsan Hospital (KR)
- Wythenshawe Hospital (GB)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Imperial College London (GB)
- University of Colorado Denver (US)
Publication Details
- Journal
- Annals of the American Thoracic Society
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1093/annalsats/aaoag071
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00