METTL3-mediated TIGAR m6A modification and its role in microglia activation related to Alzheimer’s disease

METTL3 modulates the balance of Aβ-induced polarization and microglia activation in HMC3 cells by upregulating TIGAR, promoting polarization toward an anti-inflammatory profile.

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Publication Details

Journal
Neuroreport
Published
2026-02-25
DOI
https://doi.org/10.1097/wnr.0000000000002253
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

METTL3-mediated TIGAR m6A modification and its role in microglia activation related to Alzheimer’s disease

Shiming Sun, Jing Kang, Chunying Wang, Xiaoting Zhang et al.
Neuroreport
RNA modifications and cancer
article

METTL3-mediated TIGAR m6A modification and its role in microglia activation related to Alzheimer’s disease

Shiming Sun, Jing Kang, Chunying Wang, Xiaoting Zhang, Yadong Li, Xin Du
article en

Abstract

METTL3 modulates the balance of Aβ-induced polarization and microglia activation in HMC3 cells by upregulating TIGAR, promoting polarization toward an anti-inflammatory profile.

NeuroreportVol. 37(5)
Qiqihar Medical University (CN)
Openalex Percentile: Top 12%
RNA modifications and cancer
DOISourceOpenAlex
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METTL3-mediated TIGAR m6A modification and its role in microglia activation related to Alzheimer’s disease — Shiming Sun, Jing Kang, et al. · Neuroreport (2026) | TGRS Research Map | TGRS