Isoquinolinium Photooxidant for Arene C–H Amination
We herein report a potent photocatalytic system for arene C-H amination utilizing an isoquinolinium photooxidant. The key to the process involves <i>in situ</i> protonation of neutral isoquinoline precatalyst <b>IQ1</b>. Resulting isoquinolinium <b>IQ1•H</b><sup><b>+</b></sup> exhibits a high excited-state reduction potential (+2.33 V vs SCE), enabling single-electron-transfer oxidation of inert arenes. The optimized reaction system demonstrates a broad scope, including electronically neutral arenes and various pharmaceutical small molecules with azoles and pyridines.
Authors
- Yuliang Liu (ORCID: https://orcid.org/0000-0002-6923-7351)
- Taku Wakabayashi (ORCID: https://orcid.org/0000-0002-2083-3590)
- Ye Liu (ORCID: https://orcid.org/0000-0002-8473-6538)
- Shunsuke Chiba
- Itziar Guerrero
Institutions
- Nanyang Technological University (SG)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1021/acs.orglett.6c00819
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00