Circulating Platelet–Neutrophil Aggregates as Novel Biomarker for Coagulopathy Diagnosis and Disseminated Intravascular Coagulation Prediction in Sepsis

PNA-MFI is a promising biomarker for SIC diagnosis and DIC prediction. While internally validated, external validation is essential prior to clinical implementation, and further multicenter studies are warranted to definitively establish its clinical value.

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Publication Details

Journal
Mediators of Inflammation
Published
2026-01-01
DOI
https://doi.org/10.1155/mi/5580762
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Circulating Platelet–Neutrophil Aggregates as Novel Biomarker for Coagulopathy Diagnosis and Disseminated Intravascular Coagulation Prediction in Sepsis

Cuiying Liang, Jiahui Wu, Ying Liu, Shuang Liang et al.
Mediators of Inflammation
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Circulating Platelet–Neutrophil Aggregates as Novel Biomarker for Coagulopathy Diagnosis and Disseminated Intravascular Coagulation Prediction in Sepsis

Cuiying Liang, Jiahui Wu, Ying Liu, Shuang Liang, Yu Su, Huiru Zhao, Bin Li, Hao Wang, Tenglong Dai, Xinyang Yue
article en

Abstract

PNA-MFI is a promising biomarker for SIC diagnosis and DIC prediction. While internally validated, external validation is essential prior to clinical implementation, and further multicenter studies are warranted to definitively establish its clinical value.

Mediators of InflammationVol. 2026(1)
Peking University (CN), Beijing Jishuitan Hospital (CN)
Zero hunger
Openalex Percentile: Top 14%
Sepsis Diagnosis and Treatment
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