Pharmacological inhibition of the interleukin‐1 receptor‐associated kinase prevents angiotensin II‐induced cardiac remodelling in mice
The IRAK-1/4 inhibitor reduced cardiac inflammation, fibrosis and hypertrophy through the TLR4-NF-κB and TGFβ-SMAD pathways, suggesting therapeutic potential for cardio-inflammatory heart failure.
Authors
- Manoj Kumar Barthwal (ORCID: https://orcid.org/0000-0001-7574-482X)
- Gourav Sharma
- Shreya Jaiswal
Institutions
- Jawaharlal Nehru University (IN)
- Central Drug Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1111/bph.70405
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00