Synergistic effect of combined hyperthermia and radiotherapy mediated by AQP5 reduction in pancreatic cancer
Our findings demonstrate that AQP5 plays a key role in mediating resistance to radiotherapy in PDAC. Its downregulation through combined hyperthermia and radiotherapy enhances radiosensitivity by promoting oxidative stress and blocking survival pathways. AQP5 may serve as a promising molecular target to improve the therapeutic efficacy of combined treatment strategies in pancreatic cancer.
Authors
- Geumju Park
- Minji Kang (ORCID: https://orcid.org/0000-0003-2930-4780)
- Junghwan Lee (ORCID: https://orcid.org/0000-0002-2910-479X)
- Jaewan Jeon
- S J Lee
- Hee Sun Kim (ORCID: https://orcid.org/0000-0002-7698-8794)
- Mi Lee (ORCID: https://orcid.org/0000-0001-5408-2863)
- Hyeon Jeong Hwang
- Wanyeon Kim
- Sunmi Jo
- Wonyi Jang
- Hyosun Jang
- HyeSook Youn
- BuHyun Youn
- Yong-kyu Chung
- Bo-Hyun Jung
Institutions
- Inje University (KR)
- Korea National University of Education (KR)
- Sejong University (KR)
- Korea Institute of Radiological and Medical Sciences (KR)
- Inje University Haeundae Paik Hospital (KR)
- Pusan National University (KR)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1080/02656736.2026.2644451
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00