Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation

Hyaluronic acid (HA), a naturally occurring glycosaminoglycan and major component of the extracellular matrix, has attracted increasing interest as a therapeutic adjunct in oral wound management due to its biological activity and biocompatibility. The search for the current narrative review literature was performed in the PubMed/MEDLINE, Scopus, and Web of Science databases for studies published up to December 2025. Eligible studies included experimental investigations, clinical trials, and relevant reviews assessing HA applications in oral mucosal or gingival wounds. Available clinical evidence suggests potential benefits of HA in reducing postoperative discomfort, accelerating re-epithelialization, and improving soft tissue healing following periodontal and surgical procedures. However, substantial heterogeneity exists regarding molecular weight, formulation, concentration, and application protocols, which limits direct comparison between studies and precludes definitive conclusions. Further well-designed, standardized clinical trials are required to clarify optimal formulations and confirm long-term therapeutic benefits.