CX3CL1-CX3CR1 signaling orchestrates malignant progression of prostate cancer through luminal progenitor-macrophage crosstalk
The CX3CL1-CX3CR1 axis functions as a critical mediator of reciprocal signaling between luminal-2 progenitors and TAMs that promotes immune evasion, stemness maintenance, and therapeutic resistance in prostate cancer. Disrupting this pathway impairs the pro-tumoral niche and may represent a promising therapeutic approach for advanced prostate cancer.
Authors
- Yan Guo (ORCID: https://orcid.org/0009-0009-6978-7300)
- Junyan Han (ORCID: https://orcid.org/0000-0002-5266-033X)
- Lizhuang Han (ORCID: https://orcid.org/0009-0006-7995-3673)
- Yuting Zhao (ORCID: https://orcid.org/0000-0003-4332-6329)
- Shiwei Wang (ORCID: https://orcid.org/0000-0003-3962-7241)
- Jiajia Wang
- Zhihua Liu
- Yu Jiang
- Fang Wang
- Qin Zhang
- Miaomiao Liu
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Beijing Shijitan Hospital (CN)
- Xi’an Jiaotong-Liverpool University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1007/s13402-026-01179-5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00