A Retrospective Analysis of Dengue-associated Hemophagocytic Lymphohistiocytosis in a Dengue-endemic Country
DA-HLH should be considered in pediatric patients with dengue who present with persistent fever, cytopenias, hepatic dysfunction and marked hyperferritinemia. In this exploratory analysis, elevated bilirubin appeared to reflect severe systemic and hepatic involvement rather than an independent prognostic factor, while viral coinfections may contribute to disease severity. Early recognition and individualized immunomodulatory management are essential, and larger multicenter studies are needed to validate these findings.
Authors
- María Ximena Castro García
- Paola Marsela Pérez Camacho
- Luz Ángela Urcuqui Bustamante
- Alexis Antonio Franco Moreno
- Pamela Andrea Rodríguez Riveros
- Viviana Lotero Díaz
- Harry Mauricio Pachajoa Londoño
- Manuela Olaya Hernandez
- Jaime Alberto Patiño Niño
- Diego Medina Valencia
- Vanessa Cabrera Guarín
- Oriana Arias Valderrama
- Mario Alejandro Bustos-Paz
- Jacobo Triviño Arias
- Sofía Martínez Betancur
- Daniel De Zubiría Posada
Institutions
- Fundación Valle del Lili (CO)
- Icesi University (CO)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1097/inf.0000000000005232
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00