Reliability and Validity of the Serbian Version of the Hidradenitis Suppurativa Quality of Life Questionnaire (HSQoL-24)

<b>Background:</b> Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and sinus tracts in apocrine gland-rich areas, leading to significant impairment in patients' quality of life (QoL). Persistent symptoms affect physical functioning, psychological well-being, social interactions, and intimate relationships. Therefore, validated disease-specific instruments are essential for accurate QoL assessment in different populations. <b>Objective:</b> The aim of this study was to validate the Serbian version of the Hidradenitis Suppurativa Quality of Life Questionnaire (HSQoL-24). <b>Methods:</b> The validation process followed established methodological guidelines for psychometric evaluation. The Serbian HSQoL-24 version demonstrated satisfactory psychometric properties. Internal consistency was excellent, with a Cronbach α of 0.907. Test-retest reliability was confirmed using an intraclass correlation coefficient (ICC) of 0.986 for the total score, demonstrating satisfactory reproducibility over time. A strong positive correlation was observed between the HSQoL-24 and Dermatology Life Quality Index (DLQI) total scores (Spearman's ρ = 0.806, <i>p</i> < 0.001), confirming good convergent validity, particularly in domains related to symptoms and feelings, occupational or educational functioning, and interpersonal relationships. Moreover, total HSQoL-24 scores increased significantly with disease severity, indicating the questionnaire's ability to discriminate between patients with different Hurley stages and confirming its discriminant validity. <b>Conclusions:</b> The Serbian version of the HSQoL-24 questionnaire exhibits appropriate internal consistency, test-retest reliability, and convergent and discriminant validity. These results support its use as a reliable and valid disease-specific instrument for assessing QoL in Serbian-speaking patients with HS in both clinical practice and research settings.