HIV-1 gag genotypic resistance testing using short-read and long-read next-generation sequencing technologies

Both NGS methods proved effective for gag genotyping in clinical samples, supporting their use in monitoring resistance to capsid inhibitors, although minor differences in consensus sequences were observed.

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Publication Details

Journal
Journal of Clinical Virology
Published
2026-03-24
DOI
https://doi.org/10.1016/j.jcv.2026.105939
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

HIV-1 gag genotypic resistance testing using short-read and long-read next-generation sequencing technologies

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Journal of Clinical Virology
HIV/AIDS drug development and treatment
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HIV-1 gag genotypic resistance testing using short-read and long-read next-generation sequencing technologies

Lila Poiteau, Camille Vellas, Noémie Ranger, Sofia Demmou, Pierre Delobel, Romain Carcenac, Stéphanie Raymond, Jacques Izopet, Sofiane Mohammed
article en

Abstract

Both NGS methods proved effective for gag genotyping in clinical samples, supporting their use in monitoring resistance to capsid inhibitors, although minor differences in consensus sequences were observed.

Journal of Clinical VirologyVol. 184
Centre National de la Recherche Scientifique (FR), Université Toulouse III - Paul Sabatier (FR), Inserm (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), Centre Hospitalier Universitaire de Toulouse (FR), AB Science (France) (FR), Toulouse Mathematics Institute (FR)
Openalex Percentile: Top 13%
HIV/AIDS drug development and treatment
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