Pretreatment with a histone deacetylase inhibitor, sodium butyrate, potentiates the sustained expression of myelin-associated and neurotrophic genes in cultured Schwann cells

Transient pre‑treatment with NaB enhanced and sustained the expression of certain key myelin‑associated and neurotrophic genes in Schwann cells while reducing cytotoxic effects. These findings suggest a potential strategy to improve certain Schwann cell functions and support further investigation of HDACI‑based approaches in regenerative therapy.