Comparison of Oral Cephalosporin and Penicillin Step-Down Therapy for the Treatment of Gram-Negative Blood Stream Infections: A Retrospective Observational Study

Oral cephalosporins were noninferior to oral penicillins as step-down therapy for Enterobacterales GNBSI. This represents the first comparison of oral beta-lactams for the treatment of GNBSI.

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Publication Details

Journal
Annals of Pharmacotherapy
Published
2026-03-23
DOI
https://doi.org/10.1177/10600280261426346
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparison of Oral Cephalosporin and Penicillin Step-Down Therapy for the Treatment of Gram-Negative Blood Stream Infections: A Retrospective Observational Study

Caitlin C. Akerman, Alison I. Orvin, Bethany Volkmar
Annals of Pharmacotherapy
Antibiotic Resistance in Bacteria
article

Comparison of Oral Cephalosporin and Penicillin Step-Down Therapy for the Treatment of Gram-Negative Blood Stream Infections: A Retrospective Observational Study

Caitlin C. Akerman, Alison I. Orvin, Bethany Volkmar
article en

Abstract

Oral cephalosporins were noninferior to oral penicillins as step-down therapy for Enterobacterales GNBSI. This represents the first comparison of oral beta-lactams for the treatment of GNBSI.

Annals of Pharmacotherapy
University of North Carolina at Chapel Hill (US), Prisma Health (US), Vidant Medical Center (US), WakeMed (US)
Good health and well-being
Openalex Percentile: Top 12%
Antibiotic Resistance in Bacteria
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