Ocular toxicity associated with anti-CD20 monoclonal antibodies: A pharmacovigilance analysis using the FAERS database

Anti-CD20 antibodies require careful ocular monitoring, particularly in multiple sclerosis patients. The elevated blepharospasm risks with ofatumumab and dyschromatopsia with rituximab highlights potential CNS-and optic pathway-related effects that warrant further study to improve MS treatment safety.

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Publication Details

Journal
Multiple Sclerosis and Related Disorders
Published
2026-03-23
DOI
https://doi.org/10.1016/j.msard.2026.107158
Primary Topic
Pharmacovigilance and Adverse Drug Reactions
Type
article
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Ocular toxicity associated with anti-CD20 monoclonal antibodies: A pharmacovigilance analysis using the FAERS database

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Ocular toxicity associated with anti-CD20 monoclonal antibodies: A pharmacovigilance analysis using the FAERS database

Yun Kuang, Junlong Ma, Jinlian Xie, Longjian Huang, Guoping Yang, Chengxian Guo, Yaxin Liu, Tong Li, YAN GUO, Yuxia Xiang
article en

Abstract

Anti-CD20 antibodies require careful ocular monitoring, particularly in multiple sclerosis patients. The elevated blepharospasm risks with ofatumumab and dyschromatopsia with rituximab highlights potential CNS-and optic pathway-related effects that warrant further study to improve MS treatment safety.

Multiple Sclerosis and Related DisordersVol. 109
Central South University (CN), Hunan Normal University (CN), Affiliated Hospital of Youjiang Medical University for Nationalities (CN), Third Xiangya Hospital (CN)
Zero hunger
Openalex Percentile: Top 11%
Pharmacovigilance and Adverse Drug Reactions
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