Histone Acetyltransferase KAT14 Mediates CDH5 to Regulate Spiral Artery Remodeling in Preeclampsia via Cooperation With SRF
Our study identifies KAT14 as a critical epigenetic regulator of placental spiral artery remodeling involved in preeclampsia. These findings provide novel mechanistic insights into the disease pathogenesis and identify KAT14 as a potential therapeutic target.
Authors
- Yongsheng Li (ORCID: https://orcid.org/0000-0003-2175-9449)
- Qina He
- Fei Sun
- Yanlin Ma
- Juan Li
- Linna Ma
- Yunjian Wei
- Yueying Gao
Institutions
- Harbin Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25481
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00