EVALUATION OF IMMUNOLOGICAL IMPACT OF PFASs EXPOSURE ON CYTOKINE RELEASE AND GENDER-BASED RESPONSES IN PBMCs

Per- and Perfluoroalkyl substances (PFASs) are widespread synthetic compounds known for their environmental persistence and potential health effects. Due to their bioaccumulation and resistance to degradation, PFAS exposure has raised concerns regarding the interference with immune system functions. This study explores the immunomodulatory effects of 32 different PFASs on human peripheral blood mononuclear cells (PBMCs), with a focus on gender-specific differences in cytokine responses.