Ash2l deficiency impairs adipose tissue thermogenesis and exacerbates obesity in mice
These findings establish Ash2l as a critical regulator of adipogenesis and thermogenesis. This study provides important insights into the epigenetic role of Ash2l in maintaining metabolic homeostasis under conditions of nutritional excess.
Authors
- Jie Xu (ORCID: https://orcid.org/0000-0002-9321-9567)
- Jialin Zhao (ORCID: https://orcid.org/0000-0002-1165-8911)
- Jun Chang (ORCID: https://orcid.org/0000-0001-6481-7130)
- Mengting He (ORCID: https://orcid.org/0009-0007-2987-9070)
- Wen Zhong (ORCID: https://orcid.org/0000-0001-7623-5082)
- Xing Liu (ORCID: https://orcid.org/0000-0002-7480-5085)
- Yajie Hu (ORCID: https://orcid.org/0000-0001-5976-3094)
- Chunxiang Fan
- Jiayao Liu (ORCID: https://orcid.org/0000-0003-2160-0438)
- Ruoxue Chen
- Shenhan Xu
- Chenxi Xiao
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1186/s11658-026-00892-1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00