Dose-dependent effects of Alveofact with and without steroids on neutrophil extracellular traps in neonatal respiratory distress syndrome

gov/study/NCT06367881?term=NCT06367881&rank=1 IMPACT: High-dose Alveofact + budesonide lowers NETs, PAD4, and oxidative stress. Plasma NETs strongly correlate with normalized tracheal aspirates NETs. First trial to test surfactant-steroid effects on neutrophil pathways in RDS. Therapy reduces neutrophil-mediated inflammation in preterm neonates. Plasma NETs may serve as a minimally invasive biomarker for RDS monitoring.

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Publication Details

Journal
Pediatric Research
Published
2026-03-23
DOI
https://doi.org/10.1038/s41390-026-04824-9
Primary Topic
Neonatal Respiratory Health Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Dose-dependent effects of Alveofact with and without steroids on neutrophil extracellular traps in neonatal respiratory distress syndrome

Amira M Rashad, Hisham A. Awad, Ghada I. Gad, Nashwa El-Khazragy et al.
Pediatric Research
Neonatal Respiratory Health Research
article

Dose-dependent effects of Alveofact with and without steroids on neutrophil extracellular traps in neonatal respiratory distress syndrome

Amira M Rashad, Hisham A. Awad, Ghada I. Gad, Nashwa El-Khazragy, Dina Rabie
article en

Abstract

gov/study/NCT06367881?term=NCT06367881&rank=1 IMPACT: High-dose Alveofact + budesonide lowers NETs, PAD4, and oxidative stress. Plasma NETs strongly correlate with normalized tracheal aspirates NETs. First trial to test surfactant-steroid effects on neutrophil pathways in RDS. Therapy reduces neutrophil-mediated inflammation in preterm neonates. Plasma NETs may serve as a minimally invasive biomarker for RDS monitoring.

Pediatric Research
Ain Shams University (EG)
Good health and well-being
Openalex Percentile: Top 13%
Neonatal Respiratory Health Research
DOIOpen Access PDFOpenAlex
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