Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage

The GABAAR α1-selective PAM CL218872 exerts neuroprotective and neurorestorative effects in ICH, suggesting its therapeutic potential for ICH management.

Authors

Hongli Zhou (ORCID: https://orcid.org/0000-0002-5561-2587)
Lei Xu
Tingting Chen
Junwu Liu
Fei Huang
Hongxia He

Publication Details

Journal: PLoS ONE
Published: 2026-03-23
DOI: https://doi.org/10.1371/journal.pone.0345025
Primary Topic: Intracerebral and Subarachnoid Hemorrhage Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage

Hongli Zhou, Lei Xu, Tingting Chen, Junwu Liu et al.

Mar 23, 2026

PLoS ONE

Intracerebral and Subarachnoid Hemorrhage Research

article

Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage

Hongli Zhou, Lei Xu, Tingting Chen, Junwu Liu, Fei Huang, Hongxia He

March 23, 2026article en

Abstract

The GABAAR α1-selective PAM CL218872 exerts neuroprotective and neurorestorative effects in ICH, suggesting its therapeutic potential for ICH management.

PLoS ONEVol. 21(3)

Good health and well-being

Openalex Percentile: Top 20%

Intracerebral and Subarachnoid Hemorrhage Research

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Effects of GABAAR modulators CL218872 and MRK-016 on neural repair and synaptic plasticity in mice with Intracerebral hemorrhage — Hongli Zhou, Lei Xu, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS