Indication for biologic treatment in a real-world cohort of chronic rhinosinusitis patients according to international recommendations: Evidence from the European CRS outcome registry (CHRINOSOR)
Background:In recent years, treatment options for patients with uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) have been expanded with biologics.Definitions of uncontrolled severe disease differ across international recommendations and the prescription of biologics depends on national reimbursement criteria. Objective:We aimed to evaluate the indication for biologic treatment, based on international recommendations, in a real-world cohort of CRSwNP patients.Methods: CRS patients who visited the outpatient ENT clinic of 10 tertiary centres from 7 European countries were invited to use the Galenus Health mobile application monitoring their disease.The proportion of patients who fulfilled biologic indication criteria according to EUFOREA 2021 and EPOS/EUFOREA 2023 recommendations was evaluated.Results: A total of 281 CRS patients were recruited of which 227 (82.1%) were diagnosed as CRSwNP.Out of these 227 patients, 21 patients with prior biologic use were excluded, resulting a
Authors
- Kenneth H. Larsen
- Marco de Vincentiis (ORCID: https://orcid.org/0000-0002-1990-7820)
- Z. Diamant
- Simonetta Masieri (ORCID: https://orcid.org/0000-0003-0423-9505)
- Clemens Holzmeister (ORCID: https://orcid.org/0000-0003-2835-5121)
- Sven F Seys
- Julia Eckl-Dorna
- Anette Drøhse Kjeldsen (ORCID: https://orcid.org/0000-0003-0593-6302)
- G. Mortuaire (ORCID: https://orcid.org/0000-0002-1592-1625)
- Sven Schneider (ORCID: https://orcid.org/0000-0002-7631-3746)
- P. W. Hellings
- Josje Otten (ORCID: https://orcid.org/0009-0003-5437-3005)
- Alexandros Andrianakis (ORCID: https://orcid.org/0000-0002-2530-9931)
- PV Tomazic
- Giulia Bettio
- Joost de Kinderen
- Mathilde Moyaert
- Camilo Rodriguez van Strahlen
- Gert Mariën
- L. van Gerven
- C Bachert
- Anu Laulajainen-Hongisto
- Martin Wagenmann
- Wytske J. Fokkens
- Valerie Lund
- Sietze Reitsma
- Valérie Hox
- Carlo Cavaliere
- Isam Alobid
- Joaquim Mullol
- Claire Hopkins
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University Medical Center Groningen (NL)
- University of Helsinki (FI)
- Sun Yat-sen University (CN)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Medical University of Graz (AT)
- Charles University (CZ)
- Helsinki University Hospital (FI)
- Odense University Hospital (DK)
- Vienna General Hospital (AT)
- Statistics Belgium (BE)
- Centre Hospitalier Universitaire de Lille (FR)
- Düsseldorf University Hospital (DE)
- University Hospital Münster (DE)
- Hospital Clínic de Barcelona (ES)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Royal National Throat Nose and Ear Hospital (GB)
- Thomayer University Hospital (CZ)
- Amsterdam University Medical Centers (NL)
- Hôpital Claude Huriez (FR)
- Heinrich Heine University Düsseldorf (DE)
- Medical University of Vienna (AT)
- Sapienza University of Rome (IT)
- University of Amsterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1016/j.waojou.2026.101365
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00