Interferon Regulatory Factor 3 as a Mediator and Therapeutic Target in Innate Immune-Driven Corneal Stromal Inflammation and Opacity
IRF3 is a pivotal regulator of innate immune-driven stromal inflammation and opacity. Both genetic and pharmacologic inhibition of IRF3 attenuated cytokine and myeloid responses, suggesting that targeting IRF3, potentially via piceatannol (PIC), offers a therapeutic strategy for preserving corneal transparency.
Authors
- Kyoung Woo Kim (ORCID: https://orcid.org/0000-0002-1181-5112)
- Hyunyoung Song
- Yunjin Lee (ORCID: https://orcid.org/0000-0002-5627-8314)
- Young In Yun (ORCID: https://orcid.org/0000-0003-4853-5541)
- C. J. Yoon
- Ki Hean Kim
- Ahra Koh
- Soo Jin Lee
- Seung Hyeun Lee
Institutions
- Pohang University of Science and Technology (KR)
- Seoul National University Hospital (KR)
- Gachon University Gil Medical Center (KR)
- Dongguk University Ilsan Hospital (KR)
- Chung-Ang University Hospital (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1167/iovs.67.3.49
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00