Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

An unprecedented catalyst-free cyclization reaction of easily accessed enynone and unprotected hydrazine is reported. Featuring simple reaction conditions, high efficiency and broad substrate scope, this protocol provides a practical synthetic...

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Publication Details

Journal
Chemical Communications
Published
2026-01-01
DOI
https://doi.org/10.1039/d6cc00525j
Primary Topic
Synthesis and Reactivity of Heterocycles
Type
article
Field-Weighted Citation Impact
0.00
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article

Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

Jiangan Liu, Xiaofang Li, Hu Zhou, Yimin Shangguan et al.
Chemical Communications
Synthesis and Reactivity of Heterocycles
article

Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

Jiangan Liu, Xiaofang Li, Hu Zhou, Yimin Shangguan, Yangxin Mao, Shaotong Qiu, Zhicheng Yang, Baishu Zheng, Yun-Hui Zhao, Xinlei Wang
article en

Abstract

An unprecedented catalyst-free cyclization reaction of easily accessed enynone and unprotected hydrazine is reported. Featuring simple reaction conditions, high efficiency and broad substrate scope, this protocol provides a practical synthetic...

Chemical Communications
Openalex Percentile: Top 12%
Synthesis and Reactivity of Heterocycles
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Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate — Jiangan Liu, Xiaofang Li, et al. · Chemical Communications (2026) | TGRS Research Map | TGRS