Ni-Catalyzed Natural and Unnatural Prenylation of Aryl Halides with Isoprene

We report the development of a novel nickel-hydride catalytic system for the reductive coupling of aryl halides with isoprene under mild conditions, allowing direct access to structurally diverse aryl isopentenyl compounds. The method requires no preformed metal reagents, exhibits excellent functional-group tolerance, overcomes regioselectivity challenges associated with isoprene, and provides a concise, efficient, and environmentally friendly route to natural and unnatural target products.