Diagnosis and Management of Resistant Hypertension
True resistant hypertension affects 10% of patients treated for hypertension and is diagnosed after excluding white-coat hypertension, medication nonadherence, and secondary hypertension such as primary aldosteronism. First-line treatment includes lifestyle modifications, diuretic therapy with chlorthalidone, and combination tablets of antihypertensives. Spironolactone and renal denervation decrease blood pressure in patients with true resistant hypertension.
Authors
- Wanpen Vongpatanasin (ORCID: https://orcid.org/0000-0002-7531-9388)
- Naomi D. L. Fisher
- M Azizi
- Laurence Amar
- Ajay J. Kirtane
- Felix Mahfoud
Institutions
- Brigham and Women's Hospital (US)
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- Inserm (FR)
- Université Paris Cité (FR)
- New York Hospital Queens (US)
- University Hospital of Basel (CH)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Massachusetts Institute of Technology (US)
- Columbia University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- JAMA
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1001/jama.2026.1221
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00