Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes
Our findings suggest two distinct MDD subgroups characterized by differential spatial distribution of personalized DLPFC-sgACC peak FC. These subgroups demonstrate clinical differences in both anxiety symptom severity and TMS therapeutic outcomes, warranting validation through large-sample prospective studies in the future.
Authors
- D. H. Zhang (ORCID: https://orcid.org/0009-0007-8954-1100)
- Lei Xu (ORCID: https://orcid.org/0000-0002-8499-0448)
- Gai Kong
- Sirui Wang (ORCID: https://orcid.org/0009-0007-8413-3896)
- Hongliang Zhu
- Jingjing Huang (ORCID: https://orcid.org/0000-0002-3009-8681)
- HuiRu Cui
- Chaozhe Zhu
- Jijun Wang
- Hui Li
- Yingying Tang
- Zhenying Qian
- Junjie Wang
- Lijiang Wei
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Beijing Normal University (CN)
- Shanghai Mental Health Center (CN)
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1186/s12916-026-04806-y
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00