B cell-derived exosomal miR-34a-5p mediates radiation-induced bystander effect through ferroptosis
Our findings suggest that irradiated exosomal miR-34a-5p promotes non-irradiated B cell ferroptosis through CDKN1A, uncovering a novel mechanism for RIBE and offering a new therapeutic target for radioprotection.
Authors
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Jun Deng (ORCID: https://orcid.org/0000-0003-3302-5784)
- Gangtao Sun
- Jie Yu (ORCID: https://orcid.org/0009-0007-1545-7010)
- Kui Ma
- Wenshan Zhou
Institutions
- Hubei Provincial Center for Disease Control and Prevention (CN)
- National Institute for Radiological Protection (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1515/med-2026-1375
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00