Outcomes of Percutaneous Coronary Intervention in Patients with Inflammatory Bowel Disease

<b>Background:</b> Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has been associated with elevated cardiovascular risks. However, the impact of IBD on outcomes following percutaneous coronary intervention (PCI) remains underexplored. We aimed to evaluate the clinical and procedural outcomes of PCI in patients with concurrent IBD. <b>Methods:</b> This study utilized the National Readmission Database from 2016 to 2020 to evaluate outcomes such as all-cause mortality and post-PCI complications, including various cardiovascular and gastrointestinal (GI) complications in IBD patients undergoing PCI. Patients with concurrent IBD and PCI were compared to non-IBD controls via multivariable logistic regression. <b>Results:</b> On propensity-score-matching analysis, IBD patients undergoing PCI had a higher prevalence of GI complications, including acute liver failure (Odds ratio (OR) 1.48, 95% confidence interval (CI) 1.13-1.93, <i>p</i> = 0.004), mesenteric ischemia (OR 5.34, 95% CI 1.56-18.40, <i>p</i> = 0.007), and need for blood transfusion (OR 1.74, 95% CI 1.46-2.08, <i>p</i> < 0.001). There was also a higher rate of cardiac complications (OR 1.31, 95% CI 1.05-1.64, <i>p</i> = 0.017). No significant difference in all-cause mortality (OR 0.86, 95% CI 0.72-1.04, <i>p</i> = 0.113) was observed. <b>Conclusions:</b> IBD patients undergoing PCI face increased GI and cardiovascular complications without a significant mortality difference. These findings highlight the complex interplay between systemic inflammation, vascular integrity, and procedural outcomes in IBD patients.