Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

PSC-UC neoplasia associates with transmissible microbiota-dependent inflammation and secondary BA deficiency. Controlled restoration of BA-transforming microbial functions, rather than indiscriminate secondary BA replacement, is a rational translational direction.

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Publication Details

Journal
Gut
Published
2026-03-23
DOI
https://doi.org/10.1136/gutjnl-2025-336675
Primary Topic
Liver Diseases and Immunity
Type
article
Field-Weighted Citation Impact
0.00
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article

Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

Julie Y. Zhou, Muyiwa Awoniyi, J. Roach, Deniz Coskuner et al.
Gut
Liver Diseases and Immunity
article

Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

Julie Y. Zhou, Muyiwa Awoniyi, J. Roach, Deniz Coskuner, Lianyong Su, Mohamed El Hag, Morgan Farmer, Qijun Yang, T. S. Stappenbeck, Ina Nemet, Huiping Zhou, Josue Hernandez, Nicholas Evans, Billy Ngo, R Balfour Sartor
article en

Abstract

PSC-UC neoplasia associates with transmissible microbiota-dependent inflammation and secondary BA deficiency. Controlled restoration of BA-transforming microbial functions, rather than indiscriminate secondary BA replacement, is a rational translational direction.

Gut
University of North Carolina at Chapel Hill (US), Cleveland Clinic (US), University of Richmond (US), Virginia Commonwealth University (US), University of Washington (US), Cleveland Clinic Lerner College of Medicine (US), Orthopaedic Research of Virginia (US)
Good health and well-being
Openalex Percentile: Top 15%
Liver Diseases and Immunity
DOIOpen Access PDFOpenAlex
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Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model — Julie Y. Zhou, Muyiwa Awoniyi, et al. · Gut (2026) | TGRS Research Map | TGRS