Long-term effects of L-carnitine on hyperammonemia and hepatic encephalopathy in patients with liver cirrhosis: a multicenter retrospective study
Long-term L-carnitine administration effectively reduces BAC and hepatic encephalopathy-related hospitalizations with excellent safety. Higher initial doses (>1500 mg/day) achieve more rapid BAC normalization and should be considered for patients with significant hyperammonemia.
Authors
- Shima Mimura (ORCID: https://orcid.org/0000-0002-9574-0479)
- H Tanaka
- Akio Moriya (ORCID: https://orcid.org/0000-0002-3380-6460)
- Takashi Himoto (ORCID: https://orcid.org/0000-0003-3860-2202)
- Tetsu Tomonari (ORCID: https://orcid.org/0000-0002-8484-9866)
- Kei Takuma (ORCID: https://orcid.org/0000-0003-1398-6764)
- Takuya Nagano (ORCID: https://orcid.org/0000-0003-1043-8033)
- Chikara Ogawa (ORCID: https://orcid.org/0000-0002-4534-6692)
- Akemi Tsutsui (ORCID: https://orcid.org/0000-0003-2978-2723)
- Takushi Manabe
- Teppei Sakamoto
- Rie Yano
- Hideki Kobara
- Ryosuke Imado
- Hiroki Tai
- Mai Nakahara
- Asahiro Morishita
- Joji Tani
- Tetsuji Takayama
- Koichi Takaguchi
- Tomoko Tadokoro
- Koji Fujita
- Kyoko Oura
Institutions
- Kagawa University (JP)
- Takamatsu Red Cross Hospital (JP)
- Mito Saiseikai General Hospital (JP)
- Kagawa Prefectural Central Hospital (JP)
- Kagawa Prefectural College of Health Sciences (JP)
- Tokushima University (JP)
Publication Details
- Journal
- European Journal of Gastroenterology & Hepatology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1097/meg.0000000000003171
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00