Synthesis and Properties of 1,3-Disubstituted Ureas Based on a Naphthyl Propionic Acid Derivative Naproxen
A series of 1,3-disubstituted ureas was synthesized in 85–93% yield by the reaction of 2-(1-isocyanatoethyl)-6-methoxynaphthalene with adamantyl-containing, cyclic, and aromatic amines. The synthesized ureas are promising inhibitors of human soluble epoxide hydrolase (sEH) and potential inhibitors of cyclooxygenase (COX-2).
Authors
- B. P. Gladkikh (ORCID: https://orcid.org/0000-0001-6271-0479)
- Gennady Butov (ORCID: https://orcid.org/0009-0007-5324-4788)
- Assoc. Prof. Ivan Novakov
- Vladimir Dyachenko
- Alexey D. Averin
- Abdulhamid Hussein Abdullah Al-Fanharawi
Institutions
- Lomonosov Moscow State University (RU)
- Volgograd State Technical University (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1134/s1070363225607689
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00