Differential effects of non-selective and cardio-selective beta-blocker therapy on ECG parameters in long QT syndrome type 1.
•Non-selective β-blockers markedly reduce Tpeak/end in LQT1 patients.•Cardio-selective β-blockers show no consistent effect on Tpeak/end.•The nsBB effect persists after exercise, independent of heart rate.•Tpeak/end shortening indicates decreased global repolarization heterogeneity and reduced arrhythmic risk.•Tpeak/end may serve as a novel ECG marker for β-blocker efficacy in LQT1.
Authors
- Vanessa Christe
- Saranda Nimani (ORCID: https://orcid.org/0000-0002-9298-3678)
- Marina Rieder (ORCID: https://orcid.org/0000-0002-3388-4119)
- K. E. Odening
- Rachel M A Ter Bekke
- Peter M Deissler
Institutions
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Open Access CRIS of the University of Bern
- Published
- 2026-03-23
- DOI
- https://doi.org/10.48620/96266
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00