Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model
The study highlighted two distinct protective effects of nintedanib on lung fibrosis. One well-known on mesenchymal cells and matrix-related components. Plus, one related to the involvement of the pneumocyte-macrophage paracrine lipid axis, where oxidized lipids alter macrophage activities, leading to the formation of lipid-filled macrophages. This may open new research directions.
Authors
- Gino Villetti
- Ilaria Minato (ORCID: https://orcid.org/0000-0003-1538-2585)
- F. Quaini
- Emanuela Bocchi (ORCID: https://orcid.org/0009-0001-2060-5627)
- Vanessa Pitozzi
- Caterina Frati (ORCID: https://orcid.org/0000-0002-3343-6471)
- Paola Caruso (ORCID: https://orcid.org/0000-0002-3071-1917)
- Maria Gloria Pittelli (ORCID: https://orcid.org/0000-0003-4851-699X)
- Barbara Montanini (ORCID: https://orcid.org/0000-0002-5419-7975)
- Martina Bonatti (ORCID: https://orcid.org/0000-0003-3183-6831)
- Costanza Anna Maria Lagrasta (ORCID: https://orcid.org/0000-0003-0552-9205)
- Maurizio Civelli
- Marcello Trevisani
- Silvia Pontis
- Denise Madeddu
Institutions
- University of Parma (IT)
- Chiesi Foundation (IT)
- University of Florence (IT)
- Chiesi (France) (FR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1111/bph.70311
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00