Optic Atrophy in Wolfram Syndrome Type 1: A Retrospective Analysis of Visual Outcomes and Biomarker Correlates
OA was the most common and sometimes earliest WS1 manifestation. Correlations between BCVA, OCT metrics, and mutation severity score support their potential value as biomarkers and prognostic tools. Findings also support considering genetic screening for WFS1 mutations in patients presenting with otherwise unexplained OA.
Authors
- Bradley McNeely (ORCID: https://orcid.org/0000-0002-2789-7423)
- Yunshuo Tang (ORCID: https://orcid.org/0000-0002-5524-5588)
- Devin D. Mackay (ORCID: https://orcid.org/0000-0002-6045-2565)
- Melissa W. Ko (ORCID: https://orcid.org/0000-0002-2452-9684)
- Nicholas R. Levergood
- Abby F. Tang
- Gregory P. Van Stavern
- Fumihiko Urano
Institutions
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Journal of Neuro-Ophthalmology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1097/wno.0000000000002451
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00