Administration of melatonin in small intestine damage induced by flattening filter and flattening filter free radiotherapy in rat: a histopathological and biochemical study
Melatonin significantly reduced radiotherapy-induced oxidative stress and apoptosis in healthy small intestinal tissue histopathologically and biochemically. These findings suggest that melatonin may act as an effective radioprotective agent by preserving small intestinal integrity during abdominopelvic radiotherapy.
Authors
- Tansel Sapmaz (ORCID: https://orcid.org/0000-0002-7820-5837)
- Fatih Hacımustafaoğlu
- Sude Topkaraoğlu (ORCID: https://orcid.org/0000-0002-7680-7156)
- Kübra Şevgin (ORCID: https://orcid.org/0000-0001-8250-8227)
- Esra Erdem (ORCID: https://orcid.org/0000-0001-9031-9530)
- Serhat Aras (ORCID: https://orcid.org/0000-0002-4825-5921)
- Kübra Başol Baki (ORCID: https://orcid.org/0000-0002-3533-5260)
- Selman Aktas
- Emine Kızılay
Institutions
- Defense Advanced Research Projects Agency (US)
- University of Health Science (KH)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Department of Embryology (US)
- Department of Health Services (US)
- Institute for Medical Informatics and Biostatistics (CH)
- University of Health Sciences (SO)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1080/09553002.2026.2643763
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00