Increased synovial and entheseal fibroblast activation detected by <sup>68</sup> Ga-FAPI-PET/CT is associated with the development of psoriatic arthritis in psoriasis patients with arthralgia
In psoriasis patients with arthralgia, <sup>68</sup>Ga-FAPI uptake, indicating fibroblast activation, is associated with higher BMI, more pain, subclinical US changes and concomitant OA. Pathological <sup>68</sup>Ga-FAPI uptake at articular sites was indicative of higher risk of progression to PsA in our cohort, suggesting fibroblast activation as a crucial step to develop PsA.
Authors
- Armin Atzinger
- Rita Noversa de Sousa (ORCID: https://orcid.org/0000-0003-0284-6686)
- M. G. Raimondo
- Christian Schmidkonz (ORCID: https://orcid.org/0000-0002-1988-0058)
- Giulia Corte (ORCID: https://orcid.org/0009-0007-2218-6503)
- Torsten Kuwert (ORCID: https://orcid.org/0000-0001-5682-8139)
- Filippo Fagni (ORCID: https://orcid.org/0000-0002-6122-0774)
- Alp Temiz
- Andreas Ramming
- Koray Tascilar
- Sara Bayat
- Melek Yalcin Mutlu
- Georg Schett
- Michael Sticherling
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Ostbayerische Technische Hochschule Amberg-Weiden (DE)
- Hospital Pedro Hispano (PT)
- Klinikum Weiden (DE)
Publication Details
- Journal
- RMD Open
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-006567
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00