Sex-specific associations of SHBG, testosterone, and obesity with cholecystectomy risk: a population-based cohort study
SHBG levels are inversely associated with risk of cholecystectomy in both sexes, whereas higher testosterone levels are associated with a higher risk of cholecystectomy only in women. SHBG and, to a lesser extent, testosterone accounted for a modest proportion of the obesity-cholecystectomy association in women.
Authors
- Guo‐Chong Chen (ORCID: https://orcid.org/0000-0003-1853-6244)
- Meng-Yuan Miao (ORCID: https://orcid.org/0000-0002-0834-9755)
- Jun Gu (ORCID: https://orcid.org/0000-0002-3056-9308)
- Guojian Yin (ORCID: https://orcid.org/0000-0001-5739-4491)
- Yuejia Luo (ORCID: https://orcid.org/0000-0002-3877-0081)
- Jie‐Qiong Lyu (ORCID: https://orcid.org/0009-0002-7230-7995)
- Yu-Wen Qian (ORCID: https://orcid.org/0009-0006-4804-5285)
Institutions
- Soochow University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1186/s13293-026-00884-y
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00