Tirzepatide attenuates mesolimbic cocaine-evoked dopamine levels and reduces cocaine taking, motivation and seeking behaviours in male rodents
The study is supported by grants (EJ) from the Swedish Research Council (2023-2600 and 2025-07154), LUA/ALF (grant no. 723941) from the Sahlgrenska University Hospital, Alcohol Research Council of the Swedish Alcohol Retailing Monopoly (FO2024-0048), Adlerbertska Research Foundation (2024-791), Wilhelm & Martina Lundgren's Research Foundation (2024-SA-4698) and Mary von Sydow Foundation (2024-36). This work was also supported by the following grants from the National Institutes of Health (NIH): R01 DA037897 and R01 DA061799 (H.D.S.) Thaynnam A Emous held an international internship scholarship from the São Paulo Research Foundation (FAPESP), Process Number #2023/18470-5, while conducting research at the University of Gothenburg.
Authors
- Heath D. Schmidt (ORCID: https://orcid.org/0000-0002-0646-5605)
- Christian E. Edvardsson (ORCID: https://orcid.org/0009-0004-1995-2025)
- Louise Adermark (ORCID: https://orcid.org/0000-0002-7165-9908)
- Thaynnam Arcebispo Emous (ORCID: https://orcid.org/0000-0001-8581-4182)
- Elisabet Jerlhag
- Sarah Witley
- Mia Ericson
- Xinming Zhang
Institutions
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- EBioMedicine
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1016/j.ebiom.2026.106219
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00