Application and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer

Cisplatin resistance in SCLC is a complex, multifactorial process involving cellular, molecular, and microenvironmental mechanisms. Integrating mechanistic insights with emerging therapies, including immunotherapy, targeted therapy, and novel chemotherapeutics, offers a promising path to overcome resistance, guiding future research and the development of more effective, personalized treatment strategies for patients with cisplatin-resistant SCLC.

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Publication Details

Journal
Annals of Medicine
Published
2026-03-23
DOI
https://doi.org/10.1080/07853890.2025.2601401
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Application and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer

P. Huo, Yue Shao, Junxue Dong, Mingbo Tang et al.
Annals of Medicine
Lung Cancer Research Studies
article

Application and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer

P. Huo, Yue Shao, Junxue Dong, Mingbo Tang, Min Qiang, Xinjun Zhang, Jingjun Zhu, Bowei Zhang, Jianzun Ma, Kejian Gong, Wei Liu, Zhe Chen
article en

Abstract

Cisplatin resistance in SCLC is a complex, multifactorial process involving cellular, molecular, and microenvironmental mechanisms. Integrating mechanistic insights with emerging therapies, including immunotherapy, targeted therapy, and novel chemotherapeutics, offers a promising path to overcome resistance, guiding future research and the development of more effective, personalized treatment strategies for patients with cisplatin-resistant SCLC.

Annals of MedicineVol. 58(1)
Yonsei University (KR), Jilin University (CN), Severance Hospital (KR), Peking Union Medical College Hospital (CN), Christian-Albrechts-Universität zu Kiel (DE), Max Planck Institute for Infection Biology (DE), First Hospital of Jilin University (CN), Jilin Medical University (CN), Children's Hospital of Capital Institute of Pediatrics (CN)
Good health and well-being
Openalex Percentile: Top 13%
Lung Cancer Research Studies
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