Comparative binding mechanisms of SND1 with MTDH and small-molecule inhibitors: Insights from molecular dynamics simulation and free energy calculation
The protein-protein interaction (PPI) between Metadherin (MTDH) and Staphylococcal nuclease domain-containing protein 1 (SND1) is a pivotal oncogenic driver in various cancers, yet the atomic-level details of its binding mechanism...
Authors
- Xinyu Wu (ORCID: https://orcid.org/0000-0001-6130-7821)
- Haiping Zhang (ORCID: https://orcid.org/0000-0003-2133-1768)
- Min Fang
- Tong Zhu
- ZhiXiang Yin
- Xi Zhu
- Ya Gao
- Fenghua Qi
- Jiarui Chang
Publication Details
- Journal
- Physical Chemistry Chemical Physics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5cp04225a
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00