Dapagliflozin and Crocin Ameliorate DOX-Induced Cardiotoxicity in Rats via Activating the Nrf-2/HO-1/NQO1 Pathway: A Comparative Study
DAPA is a promising new cardioprotective medication against DOX-related cardiotoxicity. Cardiotoxicity is better controlled with DAPA than Cr by suppressing oxidative stress, apoptosis, and upregulation of the antioxidant Nrf-2/HO-1/NQO1 genes.
Authors
- Mohd Khalil
- Eman Ali
- Yousra Ali Rohem Al-Ghalban
- Marwa Omar
- Eman I. El-Gizawy
- Anwaar M. Shaban
Institutions
- Department of Embryology (US)
- Universitas 17 Agustus 1945 Semarang (ID)
- Menoufia University (EG)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1080/08923973.2026.2648210
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00