Metabolomic biomarkers enhance 10-year mortality risk calibration and clinical utility in older heart failure patients: A UK Biobank study
Integrating metabolic biomarkers with standard clinical characteristics significantly improves model calibration and clinical net benefit for predicting 10-year mortality in older adults with heart failure. This approach highlights underlying mechanisms, such as mitochondrial energy dysfunction and chronic systemic inflammation, providing a practical tool for personalized care planning and targeted interventions.
Authors
- Shuli Jia (ORCID: https://orcid.org/0000-0001-9281-8173)
- Jian Xu (ORCID: https://orcid.org/0000-0001-7635-9253)
- Li Mo (ORCID: https://orcid.org/0000-0002-7564-4834)
- Chenkai Wu
- Jirong Yue
- Wenwu Cheng
- Xiaofeng Zeng
- Yan Jiang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Duke Kunshan University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1016/j.exger.2026.113093
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00